Tony,
Is this after installation, while trying to start manager? Also have you disabled UAC in Vista?
If this is the case then you should be able to go to the Win-EZ Manager.exe in the “Program FilesWin-EZ Manager” folder. Right click on the exe, and run as administrator. You should only have to do this on the first run, since manager needs to write some registry entries on startup. It may be that you have to turn UAC back on, reboot the machine, and then run as admin once to get past this issue, but I believe that we have been able to get around this problem as described above.
Let me know if this does not fix the issue.
Rob